Inhibition of immunoglobulin E attenuates pulmonary hypertension

Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) known to participate in aortic remodeling, but whether IgE mediates unknown. In the present study, we found serum elevation arterial (PAH) patients, hypoxia-induced PH mice and monocrotaline-induced rats. Neutralizing with an anti-IgE antibody was effective preventing development rat models. The receptor Fc?RI? also upregulated lung tissues Fcer1a deficiency prevented of PH. Single-cell RNA-sequencing revealed that mostly expressed mast cells (MCs) MC-specific knockout protected against mice. IgE-activated MCs produced interleukin (IL)-6 IL-13, which subsequently promoted muscularization. Clinically approved omalizumab alleviated progression established Using genetic pharmacological approaches, have demonstrated blocking IgE–Fc?RI? signaling may hold potential for PAH treatment. mouse models patients’ data, Shu, Liu, Zhou et al. show concomitant increase immunoglobulin expressing effector has important role inhibition animal